The Mystery Cartoon Character Game, ongoing-ier.

I've found it! It's Speedy, the Alka Seltzer mascot! All I had to do was look up "Jimmy Neutron, Boy Genius," and presto!

Speedy Alka Seltzer it is!

1) He was named Sparky by the creative team that dreamt him up, but the Sales Manager pointed out that the coming campaign was to be built around the idea of "speedy relief" and suggested they call him Speedy.
2) One series of commercials featured Buster Keaton.
3) Dick Beals, voice of Ralph Phillips (From A to Z-Z-Z-Z) and Davey (Davey and Goliath) among many others, was the voice of Speedy.
4) see 1)
5) In 1971 model of Speedy got lost en route to a commercials shoot in the Philippines. It turned up 5 years later in a warehouse in Australia..
6) The new voice of Speedy is Debi Derryberry, who voiced Jimmy Neutron.

Good work, Emeraldisle! Take it away...

Thanks, Pete. Now here's a good one:

1. I'm the villainess in an animated sequel to a classic live action film.

2. My henchman is a Halloween-themed creature posted in the A To Z game.

3. In the end, I'm trampled to death by my own pachyderms.

This is Mombi the witch from Journey Back to Oz.

Yes, Glowworm, you got it.

1. She was the villainess in that film.

2. Her henchman was Pumpkinhead, whom I posted in the A to Z game.

3. When she turned herself into a rose, her own elephants put an end to her.

So you go again. Good job.

Yeah, looked up the plot summery once out of curiosity. Remembered the crushed by elephants part.
Here's one for the upcoming holiday.
1. I appear in a 1997 Halloween special.
2. I am the oldest of a trio of witches.
3. Thanks to the rotten behavior of my sisters at the witches' ball last year and my inability to control them, we are banned from it this year.

I checked all the animated Halloween specials, but couldn't find one from 1997.

This must be Abnorma, from Witches in Stitches (Perennial Pictures 1997).

Good job, Peterhale. I was worried this one would be too obscure for anyone to get.
Clues are self--explainable.

Thanks.

1) In my first short I am hunted by a pair of "George and Lennie" clones. (Not that that narrows it down much!)

2) I usually like my antagonists - they are very funny fellows.

3) For my second film I have been redesigned to be more appealing (or less offensive).

Another "Speedy" character. This time, it's Speedy Gonzales.

It is indeed!

1) Cats George and Benny are run rings round by a mouse whose calling card names him as "Speedy Gonzalez" (with a final "z") when they look for prey aboard a Mexican ship in Cat-Tails for Two (1953).
2) Having outmanoeuvred his pursuer, Speedy will often turn to camera and say something along the lines of "I like heem - he is seelly".
3) In Cat-Tails for Two Speedy has buck teeth (one gold) and a bowl haircut. In Speedy Gonzales (with a final "s", 1955) his features are smaller and cuter, the teeth are gone and a tousled forelock protrudes from beneath a wide sombrero.

Over to you, Emeraldisle...

Thanks, Pete. Boy, have I got a good one:

1. I appear just once, in an episode that introduces an iconic canine's not-too-bright cousin.

2. I disguise myself as one mean crocodilian.

3. I'm more than just a little miffed about being fired from a soft drink company.

Methinks this is Alice Dovely, working as a secretary for Pa and Ma Skillett until she can learn the formula for Fenokee Fizz soda. SHe plans to sell this trademark secret to rival Kooky Cola, and doubles as the Gator Ghoul in order to destabilize the Skillett's operations. The Skilletts also are the caretakers of Scooby Dum, first cousin to Scooby Doo.

OUB, you nailed it. It is indeed Alice Dovely, and for all the reason you provided. So the board is yours again. Good job.

Goodie, I'm back in action. Oh, surprise, here's a fellow that been overlooked so far. Correcting time.

1) Technically, this character is in the public domain, since he dates way back to Greek and Roman mythology, and likely even earlier than that. In this instance, however, he's had a name change, so in this case, he's copyrighted at the moment.

2) This character first appeared in a completely animated feature film. There are humans in this debut film, but they're all animated; no real live actors goofing up this one. This character went on to appear in more animated features, mostly direct-to-video productions, plus television cartoons and video games. This fellow gets around.

3) Y'know how them astronomers go looking at the stars and planets, and when they see a new one, they get to name it? Well, one astronomer found a new heavenly body (no, not his fiancee), and gave it the same name as this character. Cool, huh?

This is another that requites a lot of thought.

Well, I'm going to throw a massive brick here and say it's Pinocchio. He fits clue three.

Well, I've learned something. There is a remote planet out there that's been named "Pinocchio" by a pair of Italian astronomers. Not much else is known about it, since it's too far away for meaningful measurement. And Pinocchio was created in 1883 by Carlo Collodi, so he's in the public domain. I could almost call this a right answer, except that Disney's copyrighted version is still named Pinocchio, and that this little wooden boy only goes back to 1883, well after the dissolution of Alexander's Conquests and the fall of the Roman Empire. True, the Achaeans had that wooden horse to gain access past the walls of Ileum, but he's not really a character, just a device.

Sorry, SaltyBoot, it's not Pinocchio, though you did succeed in making me do the research to see if Pinocchio meshed with my clues as written. Props for that.

Ohmeohmy, I'm overdue to give more clues. Better get on the stick, pronto.

4) This character is a father, and multiple times at that. His debut tends to focus on one offspring in particular. One of those problem children.

5) Despite his glorious white beard, this character is not Santa Claus. That's not a sleigh, those aren't reindeer, he tends to break toys rather than deliver them, and Santa Claus does not have that.

6) And obeying my Golden Rule: this character is not human. Doesn't even like them: "spineless ... savages." Though he mellows by the end of the first feature, I'd still keep a respectful distance from him.